Science and technology development In the science fiction film "Smitaka", the identity security of a visitor can be determined only when the gene spectrum of the visitor matches the sample file. According to EurekAlert!, the American Association for the Advancement of Science (AAAS) technology news sharing platform, researchers from Columbia University and the New York Genetic Center have developed an inexpensive DNA sequencer that can be used in conjunction with custom software to enable real-time DNA verification. Identity becomes a reality.
The research team published an article in the latest issue of eLife magazine saying that this technology is widely used to identify victims of large-scale disasters and analyze physical evidence collected at crime scenes. The most direct use is to identify errors in cancer experiments. Marked or contaminated cell lines.
In the past, gene sequencing used a credit card-sized instrument named MinION to read nucleotide sequences through microwells. However, due to factors such as high error rate, they were mostly used to study bacteria and viruses, and their use in human cells was still limited.
Now, the researchers have further innovated and closely integrated MinION, which costs only 1,000 US dollars, with on-line human genetic data to verify the identity of humans and cells with near-perfect accuracy. MinION first ranks random DNA sequences, selects individualized variants from them, and then uses the Bayesian algorithm to randomly compare variant mixtures, comparing them with variants in genetic maps already stored on other files, and quickly zooming out with each cross-check. Search scope.
The researchers reported that they used this method to compare a facial cell sample with 31,000 genome reference data on the public database DNA.land and cross-check the variants. Within minutes, it was easy to verify that the team was first The identity of the author Sophie Chaeja. Other members of the team and Columbia University students performed preliminary sequencing in a variety of genomics courses in the same way. The results were accurate and reliable.
This cross-data re-identification technique is called â€œMinION Sketch,â€ which is an inexpensive cell authentication tool that can be quickly applied to experimental research. Previous research institutions have appealed that most medical researchers either skip the verification or send it to specialized laboratories, delaying important discoveries and treatments because of the lack of expensive machines required for self-validating cell lines, and new technologies have solved this problem. The problem of wasting money. (Original title: DNA Validates Personal Identity in Just a Few Minutes)
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